1 14 benzodioxan 6 ylcarbonyl piperidine cas number 215923 54 9. Cx546 is a selective positive ampar modulator.
Positive Modulation Of Ampa Receptors Promotes Survival And
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Treatments with the ampakine cx614 markedly and reversibly increased brain derived neurotrophic factor bdnf mrna and protein levels in cultured rat entorhinalhippocampal slices 1.
Cx546. Cx 546 is an ampakine drug developed by cortex pharmaceuticals. Guide to pharmacology ligand id. The action of cx546 on ampa receptor transmission results in memory enhancement which has been demonstrated in rodents primates and humans 3.
Cx 546 was the second drug of note to come out of the cortex research program after cx 516 but while it was an improvement over its predecessor in some respects it still has problems with limited oral bioavailability. Cx 546 je organsko jedinjenje koje sadrzi 14 atoma ugljenika i ima molekulsku masu od 247290 da osobine. Cx546 98 hplc solid synonym.
Iupharbps guide to pharmacology. Molecular weight 24729. In contrast to cyclothiazide or idra 21 the ampakine cx546 binds specifically to the.
Pubchem substance id 24277960. Language label description also known as. Nagararjan et al 2001 mechanism and impact of allosteric ampa receptor modulation by the ampakine tm cx546.
Cx546 has an ec 50 in a hippocampal slice preparation of 150 mm as measured by patch clamp in cultured hippocampal neurons. This compound comes right at the heels of cx 516 another ampakine compound that showed much promise as a treatment for adhd during animal trials but proved to be disappointing when it was tested on humans. It has been proposed as a treatment for schizophrenia.
The prototypical ampakine agent. This time around the. Cx 546 is the company code given for an ampakine compound by its developer cortex pharmaceuticals.
We work hard to keep our advertising relevant and unobtrusive to create a great experience. Oneill et al 2004 ampa receptor potentiators for the treatment of cns disorders. Cx546 q5014874 from wikidata.
Empirical formula hill notation c 14 h 17 no 3. Chinamade in china cx546 at replacements ltd with links to cx546 online pattern registration form images of more than 425000 china crystal silver and collectible patterns specialty items for sale silver hollowware christmas ornaments and much more. Ampar agonist in vitro.
References are publications that support the biological activity of the product. Jump to navigation jump to search.
Positive Modulation Of Ampa Receptors Promotes Survival And
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Benzamide Type Ampa Receptor Modulators Form Two Subfamilies With
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