We prepared a fluorescent microscope with a perfusion system to smoothly exchange a buffer. Cyclothiazide is 34 dihydro 2h 124 benzothiadiazine 11 dioxide substituted at positions 3 5 and 6 by a 2 norbornen 5 yl group chlorine and a sulfonamide group respectivelya thiazide diuretic it has been used in the management of hypertension and oedema.
Cyclothiazide Semantic Scholar
Cyclothiazide Semantic Scholar
Effects Of Cyclothiazide On Glur1 Ampa Receptors Pnas
21 citations for cyclothiazide.
Cyclothiazide. Cyclothiazide is active in vivo. Chen et al 2013 the munc13 proteins differentially regulate readily releasable pool dynamics and calcium dependent recovery at a central synapse. Selected citations for cyclothiazide include.
J neurosci 33 8336 pmid. It has a role as a diuretic and an antihypertensive agent. Squid glurs displayed a strong desensitization to glutamate that was removed by cyclothiazide ctz which is a compound that stabilizes the non desensitized state of ampa receptors in vertebrates partin et al.
Cyclothiazide ctz is one of the most potent benzothiadiazides a class of positive allosteric modulators of non nmda type glutamate receptors that inhibit receptor desensitization with a marked selectivity for the flip splice variants of ampa receptors. Specifically ctz is known to produce a fast inhibition of ampa receptor desensitization and a much slower potentiation of the ampa current. Kopach et al 2011 inflammation alters trafficking of extrasynaptic ampa.
Citations are publications that use tocris products. Cyclothiazide also inhibits gaba a mediated currents and shows diuretic and convulsive actions. Cyclothiazide anhydron acquirel doburil fluidil renazide tensodiural valmiran is a benzothiadiazide diuretic and antihypertensive that was originally introduced in the united states in 1963 by eli lilly and was subsequently also marketed in europe and japan.
In the case of glua2 we added 100 mm of cyclothiazide ctz 24 min before and during glutamate treatment in order to block the desensitization partin patneau winters mayer buonanno 1993. Cyclothiazide ctz is an ampa receptor positive allosteric modulator pam which produces a fast inhibition of ampar desensitization and a slow potentiation of the ampa current.
A C Effect Of Cyclothiazide On The Amplitude And Time Course Of
A Novel Dualistic Profile Of An Allosteric Ampa Receptor Modulator
Interactions Of Gyki 52466 And Nbqx With Cyclothiazide At Ampa
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