Tyrosine kinase any of a group of enzymes that influence signaling between cells esp. Of the 90 unique tyrosine kinase genes identified in the human genome 58 encode receptor tyrosine kinase proteins.
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Axl Receptor Tyrosine Kinase Wikipedia
Receptor tyrosine kinases are part of the larger family of protein tyrosine kinases encompassing the receptor tyrosine kinase proteins which contain a transmembrane domain as well as the non receptor tyrosine kinases which do not possess transmembrane domains.
Define tyrosine kinase. Any of a group of enzymes of protein kinase that catalyze the transfer of a phosphate group from atp to a tyrosine residue in a proteins side chain. Tyrosine kinases synonyms tyrosine kinases pronunciation tyrosine kinases translation english dictionary definition of tyrosine kinases. It functions as an on or off switch in many cellular functions.
Any of a family of enzymes that phosphorylate tyrosine in certain proteins and play an important role in cell signaling. Mutations in receptor tyrosine kinases lead to activation of a series of signalling cascades which have numerous effects on protein expression. Receptor tyrosine kinases rtks are the high affinity cell surface receptors for many polypeptide growth factors cytokines and hormones.
Tyrosine kinases are a part of many cell functions including cell signaling growth and division. The phosphate group is attached to the amino acid tyrosine on the protein. Tyrosine kinases are a subclass of protein kinase.
A receptor tyrosine kinase that is involved in hematopoiesis. Fms like tyrosine kinase 3. Tyrosine kinases are implicated in several steps of neoplastic development and progression.
Any of a family of enzymes that phosphorylate tyrosine in certain proteins and play an important role in cell signaling. It is closely related to fms proto oncogene protein and is commonly mutated in acute myeloid leukemia. Some tyrosine kinase inhibitors are used to treat cancer.
Tyrosine kinase signaling pathways normally prevent deregulated proliferation or contribute to sensitivity towards apoptotic stimuli. These enzymes may be too active or found at high levels in some types of cancer cells and blocking them may help keep cancer cells from growing. Mutations that affect their activity or expression can cause leukemia and other cancers.
National library of medicine 000 0 votes rate this definition. They are a type of targeted therapy. Medical definition of tyrosine kinase.
Abnormalities in tyrosine kinases are found in some human diseases including chronic myeloid myelogenous leukemia. A tyrosine kinase is an enzyme that can transfer a phosphate group from atp to a protein in a cell. As relates to cell growth and death cellular adhesion and movement and cellular differentiation.
Tyrosine Kinase Wikipedia
Figure 1 From Defining The Role Of Tyrosine Kinase Inhibitors In
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