As discussed earlier choline is required for two types of signaling mechanisms that are fundamental modulators of the functions of many cells. Maternal choline deficiency can be induced by a number of chemicals and is manifest by histological evidence of fatty liver due to a lack of phosphatidylcholine which then restricts the export of excess triacylglycerols from the liver as well as muscle cell damage.
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Coenzyme required for nucleic acid synthesis required for maintenance of many tissues and gland fa synthesis and nucleic acid synthesis maintain tissues skin hair nerves bone marrow.
Choline is required for the synthesis of. This article needs more medical references for. It is needed for neurotransmitter synthesis acetylcholine cell membrane signaling phospholipids lipid transport lipoproteins and methyl group metabolism homocysteine reduction. Because phosphatidylcholine is required in the synthesis of very low density lipoprotein vldl particles see function choline deficiency results in impaired vldl secretion and accumulation of fat in the liver steatosis ultimately leading to liver damage.
This nutrient is required to make acetylcholine. It also seems to reduce the need to use bronchodilators. Taking choline seems to lessen symptoms and the number of days that asthma is a problem for some people.
Choline was officially recognized as an essential nutrient by the institute of medicine in 1998. Choline and other vitamins such as b12 and folate help with a process thats important for dna synthesis. It is a precursor for the widely distributed neurotransmitter acetylcholine and it is a precursor for choline phospholipids which play a vital role in the regulation of transmembrane signaling.
Dna synthesis amino acid metabolism early pregnancy. There is some evidence that higher doses of choline 3 grams daily might be more effective than lower doses 15 grams daily. Jump to navigation jump to search.
A healthy nervous system. Choline is critical in development as a precursor in the synthesis of acetylcholine phosphatidylcholine sphingomyelin and platelet activating factor and is required for metabolism of triglycerides mccann et al. Its role in the body is complex.
Neural tube formation brain and spinal cord.
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