Cx 1739 approx 3 times more potent than cx 717 halflife 72 hours patent to 2028 phase 2a completed in opioid induced respiratory depression preliminary results sept 2016 link below. Antagonism of opioid induced respiratory depression by cx1739 with preservation of opioid analgesia.
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History of allergic hypersensitivity to ampakines cx717 cx1739 remifentanil naloxone or any component of these formulations.
Cx 1739. Respirerx pharmaceuticals formerly cortex pharmaceuticals is developing cx 1739 an orally active ampa receptor agonist for the treatment of drug induced cx 1739 adisinsight either you have javascript disabled or your browser does not support javascript. In september respirerx reported preliminary data from 15 patients who achieved 25 depression of their respiratory rate following an acute iv bolus injection of 1ugkg remifentanil in the double blind stage 1 of a 2 stage crossover. Cx 1739 cortex pharmaceuticals nzt limitless.
However the unexpected discovery of the strong respiratory stimulant effects of the ampakine drugs on the pre botzinger complex of the brain has led to continued development of an intravenous formulation of cx 717 for use alongside opioid analgesics along with an oral formulation of cx 1739 which is around 3 5x more potent than cx 717 and has better oral bioavailability and is being trialled for treatment of sleep apnea. History of multiple drug allergies history or current evidence of abuse of any drug substance licit or illicit. Phase 2a completed in sleep apnea with extremely strong results seen in central type sleep apnea and good activity also seen in mixed type sleep apnea.
Respirerx filed an investigational new drug ind application with the us. Cortex has stated cx 717 as safe and well tolerated in humans however more evidence needs to be submitted to the fda before it is brought to market as an ampakine or nootropic drug. Food and drug administration fda to conduct a double blind placebo controlled dose ascending phase 2a clinical trial in approximately 18 subjects to determine the ability of orally administered cx1739 the companys lead ampakine.
Cx 1739 very little information has been released about cx 1739 by cortex pharmaceutical however it has been proposed to be 5x more potent than cx 717. Respirerx pharmaceuticals inc which develops medicines for respiratory disorders including sleep apneas and drug induced respiratory depression announces data for its cx1739 clinical study in opioid induced respiratory depression. Respirerx has completed a phase i human safety and tolerability study with cx1739 involving approximately 100 subjects tested at doses up to 1200mg per day.
Arnold lippa phd executive chairman and chief scientific officer. A phase 2 oral drug product.
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