It is available in pill form under many brand names and is used to reduce symptoms in early stage parkinsons disease. Selegiline hydrochloride usp is a levorotatory acetylenic derivative of phenethylamine.
Selegiline L Deprenyl Hydrochloride Anipryl Eldepryl Carbex
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Selegiline also known as l deprenyl is a substituted phenethylamine.
Deprenyl selegiline. The purpose of this study was to characterize the dose relationship of selegiline and desmethylselegiline pharmacokinetics within the selegiline dose range from 5 to 40 mg. There is a lot of evidence suggesting that l deprenyl selegiline anipryl eldepryl may possess significant anti aging and neuro protective properties. Selegiline is an enzyme blocker mao inhibitor that works by slowing the breakdown of certain natural substances in the brain neurotransmitters such as dopamine norepinephrine and serotonin.
Selegiline blocks the activity of mao b and at higher doses. Parkinsons disease is an incurable disorder that begins with a characteristic tremor and causes progressive disability ultimately resulting in death. Selegiline works by increasing the effect of dopamine in the brain and this helps to ease these typical symptoms.
The symptoms of parkinsons disease tremor stiffness and slow movement are due to there being less of a chemical called dopamine in your brain. Side effects of selegiline. At normal clinical doses it is a selective irreversible mao b inhibitor.
Accurate doses as little as 1 drop 1 mg can be administered at a time. Eight female subjects of whom four were using oral contraceptives ingested a single dose of 5 mg 10 mg 20 mg or 40 mg of selegiline hcl in an open four period randomized study. High doses 10 mgday of the drug stop mao a from breaking.
The chemical name is. In april 1989 the fda approved deprenyl for use against parkinsons disease a disease that usually strikes people between the ages of 50 and 70. Technically speaking it is a derivative of levomethamphetamine with a propargyl group attached to its nitrogen atom.
It can be used sublingually placed under the tongue which means it enters the blood easier and faster and is more bio available than the tablets. Selegiline also known as l deprenyl is an irreversible and relatively selective mao b inhibitor. It is commonly referred to in the clinical and pharmacological literature as l deprenyl.
In larger doses it loses its specificity and also inhibits mao a. The prime advantages of the liquid deprenyl are twofold. A mood boosting and anti aging nootropic drug.
Meta analysis of published clinical trials confirms it offers a cheap safe and effective symptomatic treatment of early parkinsons disease. 16 uses of selegiline deprenyl side effects selegiline mechanism of action. Selegiline may also be neuroprotective and act as an antidepressant.
You may be prescribed selegiline as. It increases dopamine levels in the brain. R n a dimethyl n 2 propynylphenethylamine hydrochloride.
Deprenyl belongs to a class of medications known as phenethylamines.
Metabolic Transformation Plays A Primary Role In The Psychostimulant
Anipryl Selegiline Hcl L Deprenyl Hci Tablets For Use In Dogs Only
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