123 cyclothiazide is a benzothiadiazide that acts as a potentiator of ampa receptors positively modulating its response to glutamic acid ec 50 38 um. 456 it blocks the rapid agonist induced desensitization of ampa receptors resulting in enhanced excitatory activity.
Depression Is Reduced By Cyclothiazide All Experiments Were
Depression Is Reduced By Cyclothiazide All Experiments Were
Rcsb Pdb 3tkd Crystal Structure Of The Glua2 Ligand Binding
Log kow kowwin v167 estimate 174 log kow exper.
Cyclothiazide structure. Cyclothiazide mixture with triamterene. Cyclothiazide triamterene drug combination. Cyclothiazide is a positive allosteric modulator of ionotropic a amino 3 hydroxy 5 methylisoxazole 4 propionic acid ampa type glutamate receptors with critical roles in neurological development and function.
Database match 195 exper. Predicted data is generated using the us environmental protection agencys episuite log octanol water partition coef src. It is used both within the hospital setting or for personal use to manage excess fluid associated with congestive heart failure.
Activated glua2 complex bound to glutamate cyclothiazide and stz in digitonin. Cyclothiazide functions primarily as an inhibior of the sodium chloride symporter slc12a3 in distal convoluted tubules. Structure properties spectra suppliers and links for.
Cyclothiazide is indicated as adjunctive therapy in edema and in the treatment of hypertension. Cyclothiazide is a benzothiadiazide belonging to the class of thiazide diuretics. Chlorothiazide sodium diuril is an organic compound used as a diuretic and as an antihypertensive.
Receptors for ampa are ionotropic glutamate receptors with critical roles in neurological development and function. 6 cyclothiazide is also a negative modulator of gaba a receptors reversibly inhibiting both evoked. In 1993 it was discovered that cyclothiazide is a positive allosteric modulator of the ampa and kainate receptors capable of reducing or essentially eliminating rapid desensitization of the former receptor and potentiating ampa mediated glutamate currents by as much as 18 fold at the highest concentration tested 100 mm.
Most often taken in pill form it is usually taken orally once or twice a day.
Pdb 5weo Structure Summary Protein Data Bank In Europe Pdbe
Comparison Of The Ability Of Cyclothiazide And Aniracetam To
Cyclothiazide Ampa Receptor Positive Allosteric Modulator
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