To assess the ability of stabilized g4 sequences to stall a dna polymerase we performed an in vitro dna polymerase extensionprocessivity assay 30. Cx 5461 is a dna g quadruplex stabilizer with selective lethality in brca12 deficient tumours g quadruplex dnas form four stranded helical structures and are proposed to play key roles in different cellular processes.
Cx 5461 Is A Dna G Quadruplex Stabilizer With Selective Lethality In
Cx 5461 Is A Dna G Quadruplex Stabilizer With Selective Lethality In
Cx 5461 Senhwa Biosciences Inc
Cx 5461 is a g quadruplex stabilizer in the human genome.
Cx 5461 is a dna g quadruplex stabilizer with selective lethality in brca12 deficient tumours. Targeting g quadruplex dnas for cancer treatment is a very promising prospect. Here we show that cx 5461 is a g quadruplex stabilizer with specific toxicity against brca deficiencies in cancer cells and polyclonal patient derived xenograft models including tumours resistant to parp inhibition. Here we show that cx 5461 is a g quadruplex stabilizer with specific toxicity against brca deficiencies in cancer cells and polyclonal patient derived xenograft models including tumours.
Exposure to cx 5461 and its related drug cx 3543 blocks replication forks and induces ssdna gaps or breaks. Strikingly same as pds. Targeting g quadruplex dnas for cancer treatment is a very promising prospect.
Here we show that cx 5461 is a g quadruplex stabilizer with specific toxicity against brca deficiencies in cancer cells and polyclonal patient derived xenograft models including tumours resistant to parp inhibition. Dr damian yap mbiochem oxon dic phd imperial coll lond. Cx 5461 is a dna g quadruplex stabilizer with selective lethality in brca12 decient tumours hong xu 1 marco di antonio 23 steven mckinney 1 veena mathew 4 brandon ho 5 nigel j.
In contrast bmh 21 revealed no detectable g4 binding or stabilization fig. Cx 5461 is a dna g quadruplex stabilizer with selective lethality in brca12 deficient tumours. Here we show that cx 5461 is a g quadruplex stabilizer with specific toxicity against brca deficiencies in cancer cells and polyclonal patient derived xenograft models including tumours resistant to parp inhibition.
The Structure And Function Of Dna G Quadruplexes Sciencedirect
Dna Damage And Genome Instability By G Quadruplex Ligands Are
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