Adrafinil is not a motivator and does not help me with creativity. Once the liver converts adrafinil to its active metabolites it is distributed throughout the body and affects different functions.
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Adrafinil and effects on the liver.
Adrafinil liver toxicity. This conversion process takes place in the liver. Adrafinil liver toxicity as previously mentioned there is some concern that this drug can cause liver damage especially when a person takes it for long periods of time or takes excessive doses. In the worst case scenario a build up of liver enzymes can lead to failure of the organ.
Although the exact mechanism is too complex for this article to cover just remember to ensure that your drinking adequate water to flush any toxins that can result from this process out of your body. Hence it is important to consider the possible liver toxicity in deciding on whether the addition of this drug to ones daily practice should be done. Adrafinil is a prodrug.
Liver failure occurs when large parts of the liver are damaged beyond repair meaning the liver itself can no longer function. One study on rats for example found no signs of toxicity when doses as high as 400 mg kg of body weight were administered daily for 1 month. Studies have found it to produce no toxicity even at doses far exceeding what is recommended.
It happens because the liver over metabolizes the drug effectively causing toxicity of the liver. One drawback of using adrafinil however is that it may be responsible for the build up of detrimental enzymes in the liver. I dont have enough information to tell you what the actual risk of liver damage is but id try something like alternating days and small doses of dmaa over adrafinil20 mg dmaa was useful iirc.
It is a life threatening condition necessitating immediate medical attention but most often liver failure occurs over many years and at a gradual pace. This is a problem as adrafinil increases liver enzymes which can lead to problems and eventually toxicity within the organ particularly if you already have liver issues. Adrafinil is metabolized into modafinil by way of your liver.
It is primarily metabolized in vivo to modafinil resulting in nearly identical pharmacological effects. Adrafinil liver toxicity in perspective the problem with the liver in general is that it acts as a big processing center for the body. If anything id say its detrimental to creativity.
Anything that is not excreted unchanged by the body ends up going through the liver. Despite its potent nootropic benefits adrafinil is a very safe and non toxic compound. Both are stimulants with no amphetamine like effects.
Long term supplementation of adrafinil is not advised. Adrafinil is metabolized in the liver to produce modafinil. Modafinil possesses greater selective alpha 1 adrenergic activity than adrafinil without many of adrafinils common side effects stomach pain skin irritation anxiety and with prolonged use elevated liver enzymes.
Adrafinil has also been tentatively linked to orofacial dyskinesia. Safety information on adrafinil is lacking because modafinil is often used instead for treatment of narcolepsy and excessive daytime sleepiness.
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